SEC Filing | ASLAN Pharmaceuticals

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6-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16

OF THE SECURITIES EXCHANGE ACT OF 1934

August 11, 2023

(Commission File No. 001-38475)

ASLAN PHARMACEUTICALS LIMITED

(REG. NO. 289175)

(Translation of registrant’s name into English)

CAYMAN ISLANDS

(Jurisdiction of incorporation or organization)

3 Temasek Avenue

Level 18 Centennial Tower

Singapore 039190

(Address of registrant’s principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  Form 40-F 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (1):

Yes  No 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (7):

Yes  No 

Announcement of second quarter 2023 financial results and corporate update

On August 11, 2023, ASLAN Pharmaceuticals Limited (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended June 30, 2023 and providing an update on recent corporate activities.

A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated by reference herein.

Financial Statements

On August 11, 2023, the Company issued its condensed consolidated financial statements for the six months ended June 30, 2023 (the “Financial Statements”).

A copy of the Financial Statements is attached hereto as Exhibit 99.2 and is incorporated by reference herein.

The information contained in this Form 6-K is hereby incorporated by reference into the Company’s Registration Statement on Form F-3 (File No. 333-252575), Registration Statement on Form F-3 (File No. 333-254768), Registration Statement on Form F-3 (File No. 333-270835), Registration Statement on Form F-3 (File No. 333-270837), Registration Statement on Form S-8 (File No. 333-252118), Registration Statement on Form S-8 (File No. 333-263843) and Registration Statement on Form S-8 (File No. 333-270832).

Exhibits



Exhibit Number		Exhibit Description
99.1		Press release dated August 11, 2023 regarding announcement of second quarter 2023 financial results and corporate update.
99.2		ASLAN Pharmaceuticals Limited Financial Statements for the six months ended June 30, 2023
101.INS		XBRL Instance Document
101.SCH		XBRL Taxonomy Extension Schema Document
101.CAL		XBRL Taxonomy Extension Calculation Linkbase Document
101.DEL		XBRL Taxonomy Extension Definition Linkbase Document
101.LAB		XBRL Taxonomy Extension Label Linkbase Document
101.PRE		XBRL Taxonomy Extension Presentation Linkbase Document
104		Cover Page Interactive Data File (embedded within the Inline XBRL document).

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereto duly authorized.



ASLAN PHARMACEUTICALS LIMITED
(Registrant)

By:	/s/ Kiran Kumar Asarpota
Name:	Kiran Kumar Asarpota
Title:	Chief Operating Officer

Date: August 11, 2023

EX-99.1

Exhibit 99.1

PRESS RELEASE

ASLAN PHARMACEUTICALS REPORTS SECOND QUARTER 2023 FINANCIAL RESULTS AND PROVIDES CORPORATE UPDATE

Positive topline data reported in July from TREK-AD, a Phase 2b study of eblasakimab that met the primary endpoint across three dose arms with statistical significance. The data established eblasakimab, a potential first-in-class antibody, as the first biologic in moderate-to-severe atopic dermatitis to demonstrate a competitive efficacy profile with once-monthly dosing from initiation

Data supports advancement of eblasakimab into Phase 3 clinical development program in 2024

Readouts from TREK-DX (TRials in EblasaKimab in Dupilumab eXperienced AD patients) Phase 2 study of eblasakimab and FAST-AA (FArudodstat STudy in Alopecia Areata) Phase 2a study of farudodstat both expected in the first quarter of 2024

Company maintains healthy operating position with $40.9 million in cash and cash equivalents as of June 30, 2023; $12.0 million upfront strategic license payment received in July, expected cash runway extended into the second half of 2024

San Mateo, California, and Singapore, August 11, 2023 – ASLAN Pharmaceuticals (Nasdaq: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced financial results for the second quarter ended June 30, 2023, and provided an update on recent corporate activities.

“The positive topline data from the TREK-AD Phase 2b study that we announced in July positions eblasakimab as a potential leading therapy in treating atopic dermatitis and other allergic disease. Eblasakimab is the first biologic to demonstrate a monthly dosing regimen from the start of treatment without compromising on efficacy,” said Dr Carl Firth, CEO, ASLAN Pharmaceuticals. “The topline data, in addition to the further analysis still ongoing and the supportive findings from our patient and physician surveys, support our planning of a pivotal Phase 3 study of eblasakimab, which we would expect to initiate in 2024 alongside a global commercial partner. Also this quarter, we presented translational data demonstrating that blockade of the IL-13 receptor with eblasakimab resulted in lower levels of allergy-related Th2 cytokines and pro-inflammatory Th1 cytokines when compared to blockade of the IL-4 receptor, the target of dupilumab, supporting the differentiated clinical profile demonstrated in TREK-AD.

“Additional significant accomplishments achieved during the second quarter include the initiation of the Phase 2 trial for farudodstat in alopecia areata and signing our first licensing agreement for eblasakimab in Japan with leading pharmaceutical company Zenyaku Kogyo, who will conduct additional clinical trials in this important commercial territory. With a catalyst-rich pipeline, including our upcoming data readouts in early 2024 from TREK-DX and FAST-AA, we look forward to providing updates on these important milestones,” he continued.

Second quarter 2023 and recent business highlights

Q2 and recent clinical developments

•

In May, two abstracts showcasing new data on eblasakimab and farudodstat were presented at the first International Societies for Investigative Dermatology (ISID) Meeting in Tokyo, Japan. The late-breaker abstract on eblasakimab revealed that selective targeting of IL-13Rα1 with eblasakimab may lead to more efficient reduction of Th2 inflammation without increasing levels of Th1 cytokines, compared to IL-4Rα blockade, in patients with moderate-to-severe atopic dermatitis (AD). The second late-breaker abstract showcased farudodstat’s potential to protect against immune privilege (IP) collapse in alopecia areata (AA). The posters can be accessed in the “Publications” section of ASLAN’s website.

•

In May, the first patient was dosed in the FAST-AA study, a Phase 2a proof-of-concept study of farudodstat in patients with severe AA. ASLAN expects to report interim topline data from the study, which investigates farudodstat’s efficacy and safety in patients with at least 50% scalp hair loss over a 12-week treatment period, in the first quarter of 2024.

•

In June, ASLAN and Zenyaku Kogyo Co., Ltd (Zenyaku), a leading Japanese pharmaceutical company, announced a strategic licensing agreement to develop and commercialize eblasakimab in AD and all other indications in Japan. ASLAN received an upfront payment of $12.0 million and is eligible to receive up to an additional $123.5 million in development and commercial milestones, plus tiered royalties on sales in double digit percentages ranging up to low twenties. Zenyaku plans to initiate a Phase 1 study of eblasakimab in Japan in the first half of 2024. ASLAN retains an option that can be exercised at any time to reacquire the rights to eblasakimab in Japan in the future.

•

In June, data from the Phase 1a single-ascending-dose study of eblasakimab was published in Clinical Immunology, a bimonthly, peer-reviewed journal, supporting eblasakimab’s potential as a novel, differentiated treatment for AD. The publication can be accessed here.

•

In June, preclinical data on farudodstat from ASLAN’s research collaboration with Monasterium Laboratories, a leader in the field of skin and hair research, was presented in an oral symposium at the 20th European Hair Research Society Meeting in Sheffield, UK. The presentation, titled “Exploring the potential of farudodstat, a DHODH inhibitor, as an alopecia areata therapeutic in a novel ex vivo model of human hair follicle immune privilege collapse”, showed that farudodstat has the potential to protect against IP collapse in a new translational human model of AA.

•

In July, ASLAN published a perspective article in Annals of Allergy, Asthma and Immunology, in collaboration with Emma Guttmann-Yassky MD, PhD, titled “Targeting type 2 immune activation beyond atopic dermatitis”. The article discusses the potential of a therapeutic like eblasakimab to treat a range of Type 2 driven comorbidities beyond AD. The open access article can be read here.

•

In July, ASLAN announced positive topline data from the Phase 2b dose-ranging TREK-AD (TRials with EblasaKimab in Atopic Dermatitis) study of eblasakimab that met the primary endpoint across three dose arms with statistical significance. Eblasakimab is the first biologic in moderate-to-severe AD to demonstrate a competitive efficacy profile with once-monthly dosing from initiation comparable to once every two weeks. ASLAN’s management team hosted a webcast to discuss the topline data, a recording of the webcast and presentation materials are available on ASLAN’s website.

Anticipated upcoming milestones

•

Additional data from TREK-AD on biomarkers and patient reported outcomes to be submitted for publication at a scientific congress in the fourth quarter of 2023.

•

Topline data from the TREK-DX trial of eblasakimab in dupilumab experienced patients is expected in the first quarter of 2024.

•

Topline interim data from the FAST-AA study of farudodstat is expected in the first quarter of 2024.

•

Phase 1 trial of eblasakimab in Japan is expected to be initiated by Zenyaku in the first half of 2024.

•

Meeting with the US Food and Drug Administration and subsequent initiation of the Phase 3 clinical program for eblasakimab is expected to occur in 2024.

Second quarter 2023 financial highlights

•

As of June 30, 2023, the Company had cash and cash equivalents of $40.9 million. $12.0 million upfront strategic license payment from Zenyaku received in July, extending the Company’s expected cash runway into the second half of 2024.

•

Cash used in operations for the second quarter of 2023 was $17.8 million compared to $9.7 million in the same period in 2022. The increased cash burn in the second quarter of 2023 included the settlement of $8.9 million of outstanding payables from the previous quarter.

•

Research and development expenses were $11.6 million in the second quarter of 2023 compared to $10.0 million in the second quarter of 2022. The increase was due to higher clinical development and manufacturing costs for the eblasakimab studies.

•

General and administrative expenses were $2.8 million in the second quarter of 2023 compared to $2.3 million in the second quarter of 2022.

•

Net loss attributable to stockholders for the second quarter of 2023 was $1.9 million compared to a net loss of $13.0 million for the second quarter of 2022. The decrease was due to licensing revenues of $12.0 million recognized in the second quarter of 2023.

•

The weighted average number of American Depositary Shares (ADS) outstanding in the computation of basic loss per share for the second quarter of 2023 was 16.4 million (representing 411.1 million ordinary shares) compared to 13.9 million (representing 348.7 million ordinary shares) for the second quarter of 2022. One ADS is the equivalent of twenty-five ordinary shares.

ASLAN Pharmaceuticals Limited

CONSOLIDATED BALANCE SHEETS

(In US Dollars, other than shares or share data)


	December 31, 2022 (audited)			June 30, 2023 (unaudited)
ASSETS
CURRENT ASSETS
Cash and cash equivalents	$	56,902,077		$	40,943,949
Trade receivable		—			12,000,000
Other assets		3,976,350			2,135,067
Total current assets	$	60,878,427		$	55,079,016
NON-CURRENT ASSETS
Investment in associate company		8,587			—
Property, plant and equipment		43,140			39,868
Right-of-use assets		249,601			83,197
Intangible assets		5,836			3,776
Total non-current assets		307,164			126,841
TOTAL ASSETS	$	61,185,591		$	55,205,857
LIABILITIES AND EQUITY
CURRENT LIABILITIES
Trade payables	$	12,784,485		$	6,304,936
Other payables		2,325,038			2,413,569
Lease liabilities - current		215,671			68,214
Current borrowings		7,748,831			13,382,359
Financial liabilities at fair value through profit or loss		90,213			2,189,409
Total current liabilities		23,164,238			24,358,487
NON-CURRENT LIABILITIES
Long-term borrowings		29,656,133			24,476,535
Total non-current liabilities		29,656,133			24,476,535
Total liabilities		52,820,371			48,835,022
EQUITY ATTRIBUTABLE TO STOCKHOLDERS OF THE COMPANY
Ordinary shares		63,019,962			63,700,842
Capital surplus		223,910,955			242,233,536
Accumulated deficits		(278,386,749	)		(299,384,595	)
Other reserves		(178,948	)		(178,948	)
Total equity attributable to stockholders of the Company		8,365,220			6,370,835
Total equity		8,365,220			6,370,835
TOTAL LIABILITIES AND EQUITY	$	61,185,591		$	55,205,857

ASLAN Pharmaceuticals Limited

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(In US Dollars, other than shares or share data)


	For the Three Months Ended June 30						For the Six Months Ended June 30
	2022			2023			2022			2023
NET REVENUE	$	—		$	12,000,000		$	—		$	12,000,000
COST OF REVENUE		—			—			—			—
GROSS PROFIT		—			12,000,000			—			12,000,000
OPERATING EXPENSES
General and administrative expenses		(2,319,516	)		(2,767,264	)		(4,855,049	)		(6,814,831	)
Research and development expenses		(9,980,936	)		(11,597,088	)		(19,339,046	)		(25,652,648	)
Total operating expenses		(12,300,453	)		(14,364,352	)		(24,194,095	)		(32,467,479	)
LOSS FROM OPERATIONS		(12,300,453	)		(2,364,352	)		(24,194,095	)		(20,467,479	)
NON-OPERATING INCOME AND EXPENSES
Other income		37,420			—			156,749			134
Interest income		41,373			68,911			43,797			393,458
Impairment loss of associate accounted for using equity method		(50,109	)		—			(50,109	)		—
Other gains		268,059			1,592,595			344,683			1,351,720
Finance costs		(877,300	)		(1,127,491	)		(1,960,321	)		(2,202,341	)
Total non-operating income and expenses		(580,557	)		534,015			(1,465,201	)		(457,029	)
Share in (losses)/gain of associated company, accounted for using equity method		(153,871	)		2,946			(312,372	)		(8,587	)
LOSS BEFORE INCOME TAX		(13,034,881	)		(1,827,391	)		(25,971,668	)		(20,933,095	)
INCOME TAX EXPENSE		—			(58,158	)		—			(64,751	)
NET LOSS FOR THE PERIOD		(13,034,881	)		(1,885,549	)		(25,971,668	)		(20,997,846	)
TOTAL COMPREHENSIVE LOSS FOR THE PERIOD	$	(13,034,881	)	$	(1,885,549	)	$	(25,971,668	)	$	(20,997,846	)
NET LOSS ATTRIBUTABLE TO:
Stockholders of the Company	$	(13,034,881	)	$	(1,885,549	)	$	(25,971,668	)	$	(20,997,846	)
Non-controlling interests		—			—			—			—
	$	(13,034,881	)	$	(1,885,549	)	$	(25,971,668	)	$	(20,997,846	)
TOTAL COMPREHENSIVE LOSS ATTRIBUTABLE TO:
Stockholders of the Company	$	(13,034,881	)	$	(1,885,549	)	$	(25,971,668	)	$	(20,997,846	)
Non-controlling interests		—			—			—			—
	$	(13,034,881	)	$	(1,885,549	)	$	(25,971,668	)	$	(20,997,846	)
LOSS PER ORDINARY SHARE
Basic and diluted	$	(0.04	)	$	(0.00	)	$	(0.07	)	$	(0.05	)
LOSS PER EQUIVALENT ADS
Basic and diluted	$	(0.93	)	$	(0.11	)	$	(1.86	)	$	(1.34	)
Weighted-average number of ordinary shares in the computation of basic loss per ordinary share		348,723,365			411,071,936			348,723,365			391,014,637
Weighted-average number of ADS in the computation of basic loss per ADS		13,948,935			16,442,877			13,948,935			15,640,585

About ASLAN Pharmaceuticals

ASLAN Pharmaceuticals (Nasdaq: ASLN) is a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients. ASLAN is developing eblasakimab, a potential first-in-class antibody targeting the IL-13 receptor in moderate-to-severe atopic dermatitis (AD) with the potential to improve upon current biologics used to treat allergic disease, and has recently reported positive topline data from a Phase 2b dose ranging study in moderate-to-severe AD. ASLAN is also developing farudodstat, a potent oral inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH) as a potential first-in-class treatment for alopecia areata (AA) in a Phase 2a proof-of-concept trial with an interim readout expected in 1Q 2024. ASLAN has teams in San Mateo, California, and in Singapore. For additional information please visit the website or follow ASLAN on LinkedIn.

Forward looking statements

This release contains forward-looking statements. These statements are based on the current beliefs and expectations of the management of ASLAN Pharmaceuticals Limited and/or its affiliates (the "Company"). These forward-looking statements may include, but are not limited to statements regarding the potential fees, milestone and royalty payments and development activities under the strategic license agreement; the Company’s business strategy and clinical development plans; the Company’s plans to develop and commercialize eblasakimab and farudodstat; the safety and efficacy of eblasakimab and farudodstat; the Company’s plans and expected timing with respect to manufacturing activities, clinical trials, clinical trial enrolment and clinical trial results for eblasakimab and farudodstat; the potential of eblasakimab as a first-in-class treatment for atopic dermatitis and of farudodstat as a first-in-class treatment for alopecia areata; the potential benefits, capabilities and results of the Company’s collaboration efforts; and the Company’s cash runway. The Company’s estimates, projections and other forward-looking statements are based on management's current assumptions and expectations of future events and trends, which affect or may affect the Company’s business, strategy, operations, or financial performance, and inherently involve significant known and unknown risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of many risks and uncertainties, which include, unexpected safety or efficacy data observed during preclinical or clinical studies; the fact that results of earlier studies and trials may not be predictive of future trial results; the fact that the Company will have limited control over the efforts and resources that Zenyaku devotes to advancing development programs under the strategic license agreement; the Company may not receive the potential fees and payments under the strategic license agreement or fully realize the benefits of the strategic license agreement; the Company may never exercise its option to reacquire rights to eblasakimab in Japan in the future; clinical site activation rates or clinical trial enrolment rates that are lower than expected; the impact of the COVID-19 pandemic, the ongoing conflict between Ukraine and Russia and bank failures on the Company’s business and the global economy; general market conditions; changes in the competitive landscape; and the Company’s ability to obtain sufficient financing to fund its strategic and clinical development plans. Other factors that may cause actual results to differ from those expressed or implied in such forward-looking statements are described in the Company’s US Securities and Exchange Commission filings and reports (Commission File No. 001- 38475), including the Company’s Annual Report on Form 20-F filed with the US Securities and Exchange Commission on March 24, 2023. All statements other than statements of historical fact are forward-looking statements. The words “believe,” “may,” “might,” “could,” “will,” “aim,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “plan,” or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes are intended to identify estimates, projections, and other forward-looking statements. Estimates, projections, and other forward-looking statements speak only as of the date they were made, and, except to the extent required by law, the Company undertakes no obligation to update or review any estimate, projection, or forward-looking statement.

Ends

ASLAN Media and IR contacts

Emma Thompson
Spurwing Communications
Tel: +65 6206 7350  
Email: ASLAN@spurwingcomms.com

Ashley R. Robinson
LifeSci Advisors, LLC
Tel: +1 (617) 430-7577
Email: arr@lifesciadvisors.com   

EX-99.2

Exhibit 99.2

ASLAN PHARMACEUTICALS LIMITED AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEETS

(In U.S. Dollars, other than shares or share data, or otherwise noted)

(Unaudited)


	December 31, 2022			June 30, 2023
ASSETS
CURRENT ASSETS
Cash and cash equivalents (Note 6)	$	56,902,077		$	40,943,949
Trade receivable (Note 7)		—			12,000,000
Other assets (Note 8)		3,976,350			2,135,067
Total current assets		60,878,427			55,079,016
NON-CURRENT ASSETS
Investment in associate company (Notes 9 and 10)		8,587			—
Property, plant and equipment		43,140			39,868
Right-of-use assets		249,601			83,197
Intangible assets		5,836			3,776
Total non-current assets		307,164			126,841
TOTAL ASSETS	$	61,185,591		$	55,205,857

LIABILITIES AND EQUITY
CURRENT LIABILITIES
Trade payables (Note 11)	$	12,784,485		$	6,304,936
Other payables (Note 11)		2,325,038			2,413,569
Lease liabilities – current		215,671			68,214
Current borrowings (Note 12)		7,748,831			13,382,359
Financial liabilities at fair value through profit or loss (Note 20)		90,213			2,189,409
Total current liabilities		23,164,238			24,358,487
NON-CURRENT LIABILITIES
Long-term borrowings (Note 12)		29,656,133			24,476,535
Total non-current liabilities		29,656,133			24,476,535
TOTAL LIABILITIES		52,820,371			48,835,022
EQUITY ATTRIBUTABLE TO STOCKHOLDERS OF THE COMPANY
Ordinary shares (Note 13)		63,019,962			63,700,842
Capital surplus		223,910,955			242,233,536
Accumulated deficits		(278,386,749	)		(299,384,595	)
Other reserves		(178,948	)		(178,948	)
Total equity attributable to stockholders of the Company		8,365,220			6,370,835
Total equity		8,365,220			6,370,835
TOTAL LIABILITIES AND EQUITY	$	61,185,591		$	55,205,857

The accompanying notes are an integral part of the condensed consolidated financial statements.

F-1

ASLAN PHARMACEUTICALS LIMITED AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(In U.S. Dollars, other than shares or share data, or otherwise noted)

(Unaudited)


	For the six months ended June 30
	2022			2023
NET REVENUE (Note 23)	$	—		$	12,000,000
COST OF REVENUE		—			—
GROSS PROFIT		—			12,000,000
OPERATING EXPENSES (Notes 14)
General and administrative expenses		(4,855,050	)		(6,814,831	)
Research and development expenses		(19,339,045	)		(25,652,648	)
Total operating expenses		(24,194,095	)		(32,467,479	)
LOSS FROM OPERATIONS		(24,194,095	)		(20,467,479	)
NON-OPERATING INCOME AND EXPENSES
Other income		156,749			134
Interest income		43,797			393,458
Impairment loss of associate accounted for using equity method		(50,109	)		—
Other gains and losses		344,683			1,351,720
Finance costs		(1,960,321	)		(2,202,341	)
Total non-operating expenses		(1,465,201	)		(457,029	)
Share in losses of associated company, accounted for using equity method		(312,372	)		(8,587	)
LOSS BEFORE INCOME TAX (Note 14)		(25,971,668	)		(20,933,095	)
INCOME TAX EXPENSE (Note 15)		—			(64,751	)
NET LOSS FOR THE PERIOD		(25,971,668	)		(20,997,846	)
OTHER COMPREHENSIVE LOSS
Items that will not be reclassified subsequently to profit or loss:		—			—
TOTAL COMPREHENSIVE LOSS FOR THE PERIOD	$	(25,971,668	)	$	(20,997,846	)
NET LOSS ATTRIBUTABLE TO
Stockholders of the Company	$	(25,971,668	)	$	(20,997,846	)
Non-controlling interests		—			—
	$	(25,971,668	)	$	(20,997,846	)
TOTAL COMPREHENSIVE LOSS ATTRIBUTABLE TO
Stockholders of the Company	$	(25,971,668	)	$	(20,997,846	)
Non-controlling interests		—			—
	$	(25,971,668	)	$	(20,997,846	)
LOSS PER ORDINARY SHARE (Note 16)
Basic and diluted	$	(0.07	)	$	(0.05	)
LOSS PER EQUIVALENT ADS (Note 16)
Basic and diluted	$	(1.86	)	$	(1.34	)

Each American Depository Shares (“ADS”) represented five ordinary shares before the Company completed a ratio change on March 13, 2023 (“the ADS Ratio Change”) and after the completion of the ADS Ratio Change, each ADS represents twenty-five ordinary shares. The loss per equivalent ADS had been retrospectively adjusted.

The accompanying notes are an integral part of the condensed consolidated financial statements.

F-2

ASLAN PHARMACEUTICALS LIMITED AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY

(In U.S. Dollars, other than shares or share data, or otherwise noted)

(Unaudited)

Ordinary Shares (Note 13)

Capital Surplus, share options and others

Unrealized Valuation Loss on Financial Assets at Fair Value Through Other

Number of Ordinary shares

Amount Par

Ordinary Surplus

Share Options Reserve

Equity Instruments

Other

Total

Accumulated Deficits

Comprehensive Income

Total Equity

BALANCE AT JANUARY 1, 2022

348,723,365