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ASLAN Pharmaceuticals Announces Scientific Collaboration With Dr Emma Guttman-Yassky on Identification of ASLAN004-Specific Biomarkers
MENLO PARK, Calif. and SINGAPORE, Oct. 22, 2021 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (Nasdaq: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced a collaboration with renowned inflammatory skin disease expert Dr Emma Guttman-Yassky, MD PhD, to conduct research that will continue throughout ASLAN’s Phase 2b program to identify and characterize the effects of ASLAN004 on disease-associated skin and serum-biomarkers in adults with moderate-to-severe atopic dermatitis (AD).
Dr Guttman-Yassky is Chair of the Department of Dermatology at the Icahn School of Medicine at Mount Sinai and a world leader on inflammatory skin diseases. Her research has led to significant breakthroughs in the understanding of the immunologic basis of AD, providing the scientific community with greater clarity on the pathophysiology of the disease, which is complex and multifactorial.
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Summary of recently announced key study results on ASLAN004
Data released last month from a Phase 1b MAD trial demonstrated that the key primary and secondary endpoints were met and conclusively established proof of concept, supporting the potential of ASLAN004 as a differentiated, novel treatment for AD.
In the ITT population, ASLAN004 achieved a statistically significant improvement versus placebo in the primary efficacy endpoint of percent change from baseline in Eczema Area Severity Index (EASI) and showed a greater improvement over placebo in the key efficacy endpoints. ASLAN004 also showed statistically significant improvements in other key efficacy endpoints: EASI-50, EASI-75, peak pruritus and the Patient-Oriented Eczema Measure (POEM). Importantly, ASLAN004 was shown to be well-tolerated across all doses with no emerging safety concerns.
ASLAN is on track to enroll the first patient in its global, 300-patient Phase 2b study of ASLAN004 for the treatment of AD in 4Q 2021.
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