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Varlitinib is a potent, reversible, small molecule pan-HER inhibitor and is currently being developed by ASLAN across multiple indications including a global pivotal trial in biliary tract cancer.
Initiated in 2017, the global phase 2/3 study is a double blind, randomised two-arm study that aims to determine the efficacy of varlitinib in combination with mFOLFOX6 (a combination chemotherapy regimen) in comparison to mFOLFOX6 alone in the first line setting. Topline data for the phase 2 study is expected in Q4 2018.
Gastric cancer currently ranks fourth in cancer incidence worldwide1, is the second most common cause of cancer-related deaths worldwide2 and is one of the most common types of cancer in
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|Spurwing Communications||Westwicke Partners|
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About varlitinib (ASLAN001)
Varlitinib (ASLAN001) is a highly potent, oral, reversible, small molecule pan-HER inhibitor that targets the human epidermal growth factor receptors HER1, HER2 and HER4. These receptors can be mutated or overexpressed in many tumors, which can cause excessive proliferative activity and uncontrolled growth. Therefore, by inhibiting the activation of the HER receptors, varlitinib could inhibit proliferation and control tumor growth. Varlitinib is currently being studied in gastric, biliary tract, breast and colorectal cancers. Varlitinib has been granted orphan drug designation in
About ASLAN Pharmaceuticals
Forward looking statements
This release and the accompanying financial information contains forward-looking statements. These statements are based on the current beliefs and expectations of the management of
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