ASLAN Pharmaceuticals to Present Posters on Varlitinib and ASLAN003 at European Society for Medical Oncology Congress
Varlitinib is a highly potent pan-HER inhibitor that targets the human epidermal growth factor receptors HER1, HER2 and HER4. At
30 patients were enrolled and had a median of 3 lines of prior chemotherapy. Of 28 patients evaluable for response, 3 showed partial response (PR), 16 experienced stable disease (SD) and the disease control rate (PR and SD for at least 12 weeks) was 46%. The maximum tolerated dose for varlitinib in combination with COX and FOL was 300mg BID and durable efficacy was seen in patients with biliary cancers and colorectal cancer, with 5 patients having progression free survival over 220 days up to 645 days.
ASLAN003 is an orally active, potent inhibitor of dihydroorotate dehydrogenase (DHODH) that has the potential to be first-in-class in acute myeloid leukaemia (AML). ASLAN003 has demonstrated the ability to induce differentiation in AML cell lines, xenograft models, and the primary AML blast obtained from patients. In a second poster, ASLAN will present the study design of an ongoing phase 2A dose optimisation study of ASLAN003 as monotherapy in AML patients who are ineligible for standard therapy.
Details of the presentations:
Poster Number: 430P
Abstract Title: Phase I study: Safety and tolerability of varlitinib (VAR) in combination with Oxaliplatin and Capecitabine (COX) or Oxaliplatin and 5-FU (FOL) in advanced solid tumours
Session Title: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Date/Time:
Location: Hall A3 - Poster Area Networking Hub, ICM München,
Poster Number: 1043TiP
Abstract Title: A phase IIA dose optimization study of ASLAN003 in acute myeloid leukemia (AML)
Session Title: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC – early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Date and time:
Location: Hall A3 - Poster Area Networking Hub, ICM München,
The abstracts are available online at: https://www.esmo.org/.
Media and IR contacts
Emma Thompson Spurwing Communications Tel: +65 6340 7287 Email: ASLAN@spurwingcomms.com |
Robert Uhl Westwicke Partners Tel: +1 858 356 5932 Email: robert.uhl@westwicke.com |
About varlitinib (ASLAN001)
Varlitinib (ASLAN001) is a highly potent, oral, reversible, small molecule pan-HER inhibitor that targets the human epidermal growth factor receptors HER1, HER2 and HER4. These receptors can be mutated or overexpressed in many tumors, which can cause excessive proliferative activity and uncontrolled growth. Therefore, by inhibiting the activation of the HER receptors, varlitinib could inhibit proliferation and control tumor growth. Varlitinib is currently being studied in gastric, biliary tract, breast and colorectal cancers. Varlitinib has been granted orphan drug designation in
About ASLAN003
ASLAN003 is an orally active, potent inhibitor of DHODH that has the potential to be first-in-class in acute myeloid leukaemia (AML). Licensed from
About
Source: ASLAN Pharmaceuticals Limited