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ASLAN Pharmaceuticals to Present Positive varlitinib Data in First-Line Biliary Tract Cancer in Combination With Chemotherapy at ASCO GI
16 patients completed the first cycle of chemotherapy with at least one post treatment scan and were evaluable for efficacy. Seven patients showed partial response (PR) and eight had stable disease (SD) for more than 12 weeks. The overall response rate (ORR) and disease control rate (DCR) for both cohorts were 43.8% and 93.8% respectively. In the 200 mg BID cohort, 4/11 patients achieved PR and 6/11 had SD with ORR and DCR of 36.4% and 90.9% respectively. In the 300 mg BID cohort, 3/5 patients achieved PR and 2/5 had SD with ORR and DCR of 60% and 100% respectively. These results compare favourably with the published historical results in the
Varlitinib has been well tolerated in BTC patients treated to date. The incidence and severity of adverse events was comparable in both dose cohorts with the most frequently reported adverse events being decreases in platelet count and neutrophil count. ASLAN is continuing to recruit patients into the 300mg BID dose cohort to complete the phase 1b part of the clinical trial.
At ASCO GI, ASLAN will also present a poster on safety and efficacy data from a pooled analysis of three phase 1 clinical trials (ASLAN001-002, ASLAN001-002SG, and ASLAN001-007) of varlitinib in combination with various doublet chemotherapies (5-flourouracil or capecitabine or gemcitabine) that contained a platinum-based regimen (cisplatin or oxaliplatin), in advanced BTC patients that were either: 1st line, 2nd line, 3rd line or >3rd line.
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Source: ASLAN Pharmaceuticals Limited